Candice Contet's Yesterday

Since its inception in 2011, the Contet laboratory has been investigating how proteins known to be modulated by ethanol in vitro may contribute to the behavioral effects of alcohol in vivo. This line of research revealed a key role for G-protein-gated inwardly rectifying potassium (GIRK) channels in binge drinking and implicated large conductance, calcium- and voltage-activated potassium (BK) channels in the behavioral adaptations triggered by chronic exposure to alcohol, such as tolerance to intoxication and drinking escalation.