Publications Acknowledging Support by the Pearson Center

Koob GF, Mason BJ. Existing and future drugs for the treatment of the dark side of addiction. Annual Review of Pharmacology and Toxicology, 2016, 56:299-322.

*Free full text at Annual Reviews


 

Koob GF. The neurobiology of reward and stress and its relevance for understanding drug-seeking and dependence symptomatology. In: Sher KJ (ed) Oxford Handbook of Substance Use and Substance Use Disorders. Oxford University Press, New York, 2016, pp. 166-191.

*Abstract at Oxford Handbooks Online


de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a neuronal ensemble in the central nucleus of the amygdala is required for alcohol dependence. Journal of Neuroscience, 2016, 36:9446-9453.

*PMC Free Full Text Article


Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. Journal of Clinical Investigation, 2015, 125:3193-3197.

*PMC Free Full Text Article


Koob GF. Neurobiology of addiction. In: Galanter M, Kleber HD, Brady KT (eds) Textbook of Substance Abuse Treatment, 5th edition. American Psychiatric Publishing, Washington DC, 2015, pp. 3-24.

*More info at psychiatryonline


Cui C, Noronha A, Warren KR, Koob GF, Sinha R, Thakkar M, Matochik J, Crews FT, Chandler LJ, Pfefferbaum A, Becker HC, Lovinger D, Everitt BJ, Egli M, Mandyam CD, Fein G, Potenza MN, Harris RA, Grant KA, Roberto M, Meyerhoff DJ, Sullivan EV. Brain pathways to recovery from alcohol dependence. Alcohol, 2015, 49:435-452.

*PMC Free Full Text Article


Schmeichel BE, Barbier E, Misra KK, Contet C, Schlosburg JE, Grigoriadis D, Williams JP, Karlsson C, Pitcairn C, Heilig M, Koob GF, Vendruscolo LF. Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats. Neuropsychopharmacology, 2015, 40:1123-1129.

*PMC Free Full Text Article


Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology, 2015, 232:453-463.

*PMC Free Full Text Article


Whitfield TW Jr, Schlosburg J, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. Journal of Neuroscience, 2015, 35:4296-4305.

*PMC Free Full Text Article


Wade CL, Vendruscolo LF, Schlosburg JE, Hernandez DO, Koob GF. Compulsive-like responding for opioid analgesics in rats with extended access. Neuropsychopharmacology, 2015, 40:421-428.

*PMC Free Full Text Article


Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. Extended access to nicotine leads to a CRF(1) receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology, 2015, 20:56-68.

*PMC Free Full Text Article


Koob GF. Neurocircuitry of alcohol addiction: synthesis from animal models. In: Sullivan EV, Pfefferbaum A (eds) Alcohol and the Nervous System (series title: Handbook of Clinical Neurology, vol. 125). Elsevier, Amsterdam, 2014, pp. 33-54.

*Abstract at ScienceDirect


Koob GF. Frameworks of alcohol addiction: alcohol addiction as a reward deficit disorder. In: Noronha ABC, Cui C, Harris RA, Crabbe JC (eds) Neurobiology of Alcohol Dependence. Elsevier, Amsterdam, 2014, pp. 3-28.

*More info at Elsevier


Zorrilla EP, Koob GF. Amygdalostriatal projections in the neurocircuitry for  motivation: a neuroanatomical thread through the career of Ann Kelley. Neuroscience and Biobehavioral Reviews, 2013, 37:1932-1945.

*PMC Free Full Text Article


Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj  JC, George O, Koob GF, Mandyam CD. Hippocampal neurogenesis protects against cocaine-primed relapse. Addiction Biology, 2014, 19:562-574.

*PMC Free Full Text Article


Buck CL, Vendruscolo LF, Koob GF, George O. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology, 2014, 231:929-937.

*PMC Free Full Text Article


Logrip ML, Vendruscolo LF, Schlosburg JE, Koob GF, Zorrilla EP. Phosphodiesterase 10A regulates alcohol and saccharin self-administration in rats. Neuropsychopharmacology, 2014, 39:1722-1731.

*PMC Free Full Text Article


Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. Anticipatory 50kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behavioural Brain Research, 2014, 271:171-176.

*PMC Free Full Text Article


Vanderlinden LA, Saba LM, Printz MP, Flodman P, Koob G, Richardson HN, Hoffman PL, Tabakoff B. Is the alcohol deprivation effect genetically mediated? Studies with HXB/BXH recombinant inbred rat strains. Alcoholism: Clinical and Experimental Research, 2014, 38:2148-2157.

*PMC Free Full Text Article


Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW Jr, George O. Addiction as a stress surfeit disorder. Neuropharmacology, 2014, 76:370-382.

*PMC Free Full Text Article


Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. PLoS One, 2014, 9:e97216.

*PMC Free Full Text Article


Schlosburg JE, Whitfield TW Jr, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. Journal of Neuroscience, 2013, 33:19384-19392.

*PMC Free Full Text Article


Kallupi M, Wee S, Edwards S, Whitfield TW Jr, Oleata CS, Luu G, Schmeichel BE, Koob GF, Roberto M. Kappa opioid receptor-mediated dysregulation of gamma-aminobutyric acidergic transmission in the central amygdala in cocaine addiction. Biological Psychiatry, 2013, 74:520-528.

*PMC Free Full Text Article


Koob GF. Neuroscience of addiction. In: McCrady BS, Epstein EE (eds) Addictions: A Comprehensive Guidebook, 2nd edition. Oxford University Press, Oxford, 2013, pp. 17-35.

*Excerpt at Google Books

*More info at Oxford University Press


Schlosburg JE, Vendruscolo LF, Bremer PT, Lockner JW, Wade CL, Nunes AAK, Stowe GN, Edwards S, Janda KD, Koob GF. Dynamic vaccine blocks relapse to compulsive intake of heroin. Proceedings of the National Academy of Sciences USA, 2013, 110:9036-9041.

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Koob GF. Addiction is a reward deficit and stress surfeit disorder. Frontiers in Addictive Disorders and Behavioral Dyscontrol, 2013, 4:72.

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Park PE, Vendruscolo LF, Schlosburg JE, Edwards S, Schulteis G, Koob GF. Corticotropin-releasing factor (CRF) and α2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats. International Journal of Neuropsychopharmacology, 2013, 16:1867-1875.

*PMC Free Full Text Article


Barbier E, Vendruscolo LF, Schlosburg JE, Edwards S, Juergens N, Park PE, Misra KK, Cheng K, Rice KC, Schank J, Schulteis G, Koob GF, Heilig M. The NK1 receptor antagonist L822429 reduces heroin reinforcement. Neuropsychopharmacology, 2013, 38:976-984.

*PMC Free Full Text Article


Edwards S, Koob GF. Escalation of drug self-administration as a hallmark of persistent addiction liability. Behavioural Pharmacology, 2013, 24:356-362.

*PMC Free Full Text Article


Edwards S, Baynes BB, Carmichael CY, Zamora-Martinez ER, Barrus M, Koob GF, Gilpin NW. Traumatric stress reactivity promotes excessive alcohol drinking and alters the balance of prefrontal cortex-amygdala activity. Translational Psychiatry, 2013, 3:e296.

*PMC Free Full Text Article


Jang CG, Whitfield T, Schulteis G, Koob GF, Wee S. A dysphoric-like state during early withdrawal from extended access to methamphetamine self-administration in rats. Psychopharmacology, 2013, 225:753-763.

*PMC Free Full Text Article


Mandyam CD, Koob GF. The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. Trends in Neurosciences, 2012, 35:250-260.

*PMC Free Full Text Article


Wee S, Vendruscolo LF, Misra KK, Schlosburg JE, Koob GF. A combination of buprenorphine and naltrexone blocks compulsive cocaine intake in rodents without producing dependence. Science Translational Medicine, 2012, 4:146ra110.

*PMC Free Full Text Article


Edwards S, Koob GF. Experimental psychiatric illness and drug abuse models: from human to animal, an overview. In: Kobeissy H (ed) Psychiatric Disorders: Methods and Protocols (series title: Methods in Molecular Biology, vol 829). Springer, New York, 2012, pp. 31-48.

*PMC Free Full Text Article


Koob GF. Neuroanatomy of addiction. In: Brownell KD, Gold MS (eds) Food and Addiction: A Comprehensive Handbook. Oxford University Press, Oxford, 2012, pp. 20-29.

*More info at Oxford University Press


Koob GF. Animal models of drug addiction. In: Brownell KD, Gold MS (eds) Food and Addiction: A Comprehensive Handbook. Oxford University Press, Oxford, 2012, pp. 3-13.

*More info at Oxford University Press


Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology, 2012, 223:159-168.

*PMC Free Full Text Article


Koob GF. Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction: alcohol addiction as a reward deficit disorder. In: Sommer WH, Spanagel R (eds) Behavioral Neurobiology of Alcohol Addiction (series title: Current Topics in Behavioral Neuroscience, vol 13), Springer-Verlag, Berlin, 2012, pp. 3-30.

*PMC Free Full Text Article


Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology, 2012, 223:17-25.

*PMC Free Full Text Article


George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences USA, 2012, 109:18156-18161.

*PMC Free Full Text Article


George O, Le Moal M, Koob GF. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiology and Behavior, 2012, 106:58-64.

*PMC Free Full Text Article


Egli M, Koob GF, Edwards S. Alcohol dependence as a chronic pain disorder. Neuroscience and Biobehavioral Reviews, 2012, 36:2179-2192.

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Cohen A, Koob GF, George O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology, 2012, 37:2153-2160.

*PMC Free Full Text Article


Recinto P, Samant ARH, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology, 2012, 37:1275-1287.

*PMC Free Full Text Article


Edwards S, Vendruscolo LF, Schlosburg JE, Misra KK, Wee S, Park PE, Schulteis G, Koob GF. Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF1 receptor antagonism. Neuropharmacology, 2012, 62:1142-1151.

*PMC Free Full Text Article


Logrip ML, Zorrilla EP, Koob GF. Stress modulation of drug self-administration: implications for addiction comorbidity with post-traumatic stress disorder. Neuropharmacology, 2012, 62:552-564.

*PMC Free Full Text Article


Vendruscolo LF, Barbier E, Schlosburg JE, Misra KK, Whitfield T Jr, Logrip ML, Rivier CL, Repunte-Canonigo V, Zorrilla EP, Sanna PP, Heilig M, Koob GF. Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats. Journal of Neuroscience, 2012, 32:7563-7571.

*PMC Free Full Text Article


Edwards S, Guerrero M, Ghoneim OM, Roberts E, Koob GF. Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats. Addiction Biology, 2012, 17:76-85.

*PMC Free Full Text Article


George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology, 2011, 213:715-722.

*PMC Free Full Text Article


Parylak SL, Koob GF, Zorrilla EP. The dark side of food addiction. Physiology and Behavior, 2011, 104:149-156.

*PMC Free Full Text Article


Vendruscolo L, Schlosburg JE, Misra KK, Chen SA, Greenwell TN, Koob GF. Escalation patterns of varying periods of heroin access. Pharmacology Biochemistry and Behavior, 2011, 98:570-574.

*PMC Free Full Text Article


Sabino V, Cottone P, Blasio A, Iyer MR, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. Activation of σ-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. Neuropsychopharmacology, 2011, 36:1207-1218.

*PMC Free Full Text Article


Koob GF. Animal models of drug dependence: motivational perspective. In: Johnson BA (ed) Addiction Medicine: Science and Practice. Springer, New York, 2011, pp. 333-357.

*More info at Springer


Ali SF, Onaivi ES, Dodd PR, Cadet JL, Schenk S, Kuhar MJ, Koob GF. Understanding the global problem of drug addiction is a challenge for IDARS scientists. Current Neuropharmacology, 2011, 9:2-7.

*PMC Free Full Text Article


Logrip ML, Koob GF, Zorrilla EP. Role of corticotropin-releasing factor in drug addiction: potential for pharmacological intervention. CNS Drugs, 2011, 25:271-287.

*PMC Free Full Text Article


Allen CD, Lee S, Koob GF, Rivier C. Immediate and prolonged effects of alcohol exposure on the activity of the hypothalamic-pituitary-adrenal axis in adult and adolescent rats. Brain, Behavior, and Immunity, 2011, 25:S50-S60.

*PMC Free Full Text Article


Gilpin NW, Misra K, Herman MA, Cruz MT, Koob GF, Roberto M. Neuropeptide Y opposes alcohol effects on gamma-aminobutyric acid release in amygdala and blocks the transition to alcohol dependence. Biological Psychiatry, 2011, 69:1091-1099.

*PMC Free Full Text Article


Zorrilla EP, Wee S, Zhao Y, Specio S, Boutrel B, Koob GF, Weiss F. Extended access cocaine self-administration differentially activates dorsal raphe and amygdala corticotropin-releasing factor systems in rats. Addiction Biology, 2011, 17:300-308.

*PMC Free Full Text Article


Gilpin NW, Koob GF. Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats. Psychopharmacology, 2010, 212:431-439.

*PMC Free Full Text Article


Koob GF, Le Moal M. Neurobiological mechanisms for opponent motivational processes in addiction. In: Robbins TW, Everitt BJ, Nutt DJ (eds) The Neurobiology of Addiction: New Vistas, Oxford University Press, Oxford, 2010, pp. 7-23.

*Free full text at The Royal Society Publishing


Koob GF, Le Moal M. The role of dopamine in the motivational vulnerability to addiction. In: Iversen LL, Iversen SD, Dunnett SB, Bjorklund A (eds) Dopamine Handbook. Oxford University Press, Oxford, 2010, pp. 371-388.

*Abstract at Oxford Scholarship Online


Shurman J, Koob GF, Gutstein HB. Opioids, pain, the brain, and hyperkatifeia: a framework for the rational use of opioids for pain. Pain Medicine, 2010, 11:1092-1098.

*PMC Free Full Text Article


George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews, 2010, 35:232-247.

*PMC Free Full Text Article


Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology Reviews, 2010, 35:217-238 [erratum: 35:1051].

*PMC Free Full Text Article

*Erratum


Edwards S, Koob GF. Neurobiology of dysregulated motivational systems in drug addiction. Future Neurology, 2010, 5:393-410.

*PMC Free Full Text Article


Zorrilla EP, Koob GF. Progress in corticotropin-releasing factor-1 antagonist development. Drug Discovery Today, 2010, 15:371-383.

*PMC Free Full Text Article


Koob GF, Zorrilla EP. Neurobiological mechanisms of addiction: focus on corticotropin-releasing factor. Current Opinion in Investigational Drugs, 2010, 11:63-71.

*PMC Free Full Text Article


Koob GF. The role of CRF and CRF-related peptides in the dark side of addiction. Brain Research, 2010, 1314:3-14.

*PMC Free Full Text Article


Roberto M, Cruz MT, Gilpin NW, Sabino V, Schweitzer P, Bajo M, Cottone P, Madamba SG, Souffer DG, Zorrilla EP, Koob GF, Siggins GR, Parsons LH. Corticotropin releasing factor-induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence. Biological Psychiatry, 2010, 67:831-839.

*PMC Free Full Text Article


Walker BM, Zorrilla EP, Koob GF. Systemic κ-opioid receptor antagonism by nor-binaltorphimine reduces dependence-induced excessive alcohol self-administration in rats. Addiction Biology, 2010, 16:116-119.

*PMC Free Full Text Article


Orio L, Wee S, Newman AH, Pulvirenti L, Koob GF. The dopamine D3 receptor partial agonist CJB090 and antagonist PG 01037 decrease progressive ratio responding for methamphetamine in rats with extended-access. Addiction Biology, 2010, 15:312-323.

*PMC Free Full Text Article


Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcohol-preferring rats by a sigma-1 receptor antagonist. Psychopharmacology, 2009, 205:327-335.

*PMC Free Full Text Article


Francesconi W, Berton F, Koob GF, Sanna PP. Intrinsic neuronal plasticity in the juxtacapsular nucleus of the bed nuclei of the stria terminalis (jcBNST). Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2009, 33:1347-1355.

*PMC Free Full Text Article


Koob GF. Neurobiology of addiction. In: Cohen LM, Collins FL Jr, Young AM, McChargue DE, Leffingwell TR, Cook KL (eds) Pharmacology and Treatment of Substance Abuse: Evidence- and Outcome-Based Perspectives, Routledge, New York, 2009, pp. 85-108.

*More info at Taylor & Francis eBooks


Koob GF. Addiction: neurobiological mechanism. In: Squire LR (ed) Encyclopedia of Neuroscience, vol 1. Academic Press, Oxford, 2009, pp. 75-81.

*Abstract at ScienceDirect


Cottone P, Sabino V, Roberto M, Bajo M, Pockros L, Frihauf JB, Fekete EM, Steardo L, Rice KC, Grigoriadis DE, Conti B, Koob GF, Zorrilla EP. CRF system recruitment mediates dark side of compulsive eating. Proceedings of the National Academy of Sciences USA, 2009, 106:20016-20020.

*PMC Free Full Text Article


Koob GF. Dynamics of neuronal circuits in addiction: reward, antireward, and emotional memory. Pharmacopsychiatry, 2009, 42(suppl 1):s32-s41.

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Greenwell TN, Walker BM, Cottone P, Zorrilla EP, Koob GF. The α1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration. Pharmacology Biochemistry and Behavior, 2009, 91:295-302.

*PMC Free Full Text Article


Sabino V, Cottone P, Zhao Y, Iyer MR, Steardo L Jr, Steardo L, Rice KC, Conti B, Koob GF, Zorrilla EP. The σ-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology, 2009, 34:1482-1493.

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Koob GF. Neurobiological substrates for the dark side of compulsivity in addiction. Neuropharmacology, 2009, 56:18-31.

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Richardson HN, Chan SH, Crawford EF, Lee YK, Funk CK, Koob GF, Mandyam CD. Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence. Neurobiology of Disease, 2009, 36:1-10.

*PMC Free Full Text Article


Koob GF, Lloyd GK, Mason BJ. Development of pharmacotherapies for drug addiction: a Rosetta Stone approach. Nature Reviews Drug Discovery, 2009, 8:500-515.

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Orio L, Edwards S, George O, Parsons LH, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in extended access conditions. Journal of Neuroscience, 2009, 29:4846-4857.

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Koob GF. Brain stress systems in the amygdala in addiction. Brain Research, 2009, 1293:61-75.

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Tabakoff B, Saba L, Printz M, Flodman P, Hodgkinson C, Goldman D, Koob G, Richardson HN, Kechris K, Bell RL, Hübner N, Heinig M, Pravenec M, Mangion J, Legault L, Dongier M, Conigrave KM, Whitfield JB, Saunders J, Grant B, Hoffman PL. Genetical genomic determinants of alcohol consumption in rats and humans. BMC Biology, 2009, 7:70.

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Gilpin NW, Smith AD, Cole MD, Weiss F, Koob GF, Richardson HN. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcoholism: Clinical and Experimental Research, 2009, 33:2113-2123.

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Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, Rice K, Zorrilla EP, Koob GF. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long-, but not short-access rats. Addiction Biology, 2009, 14:130-143.

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Specio SE, Wee S, O’Dell LE, Boutrel B, Zorrilla EP, Koob GF. CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats. Psychopharmacology, 2008, 196:473-482.

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Koob GF, Le Moal M. Neurobiological mechanisms for opponent motivational processes in addiction. Philosophical Transactions of the Royal Society of London B Biological Sciences, 2008, 363:3113-3123.

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Gilpin NW, Misra K, Koob GF. Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking. Pharmacology Biochemistry and Behavior, 2008, 90:475-480.

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Richardson HN, Zhao Y, Fekete EM, Funk CK, Wirsching P, Janda KD, Zorrilla EP, Koob GF. MPZP: a novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist. Pharmacology Biochemistry and Behavior, 2008, 88:497-510.

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Koob GF. A role for brain stress systems in addiction. Neuron, 2008, 59:11-34.

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Koob GF. The role of animal models in reward deficit disorders: views from academia. In: McArthur RA, Borsini F (eds) Animal and Translational Models of CNS Drug Discovery: Volume 3. Reward Deficit Disorders. Academic Press, London, 2008, pp. 59-89.

*More info at ScienceDirect


Richardson HN, Lee SY, O’Dell LE, Koob GF, Rivier CL. Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. European Journal of Neuroscience, 2008, 28:1641-1653.

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Koob GF. Hedonic homeostatic dysregulation as a driver of drug-seeking behavior. Drug Discovery Today: Disease Models, 2008, 5:207-215.

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Ji D, Gilpin NW, Richardson HN, Rivier CL, Koob GF. Effects of naltrexone, duloxetine, and a corticotropin-releasing factor type 1 receptor antagonist on binge-like alcohol drinking in rats. Behavioural Pharmacology, 2008, 19:1-12.

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Gilpin NW, Richardson HN, Lumeng L, Koob GF. Dependence-induced alcohol drinking by alcohol-preferring (P) rats and outbred Wistar rats. Alcoholism: Clinical and Experimental Research, 2008, 32:1688-1696.

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Gilpin NW, Richardson HN, Koob GF. Effects of CRF1-receptor and opioid-receptor antagonists on dependence-induced increases in alcohol drinking by alcohol-preferring (P) rats. Alcoholism: Clinical and Experimental Research, 2008, 32:1535-1542.

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Gilpin NW, Koob GF. Neurobiology of alcohol dependence: focus on motivational mechanisms. Alcohol Research and Health, 2008, 31:185-195.

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Walker BM, Rasmussen DD, Raskind MA, Koob GF. α1-Noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol. Alcohol, 2008, 42:91-97.

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Heilig M, Koob GF. A key role for corticotropin-releasing factor in alcohol dependence. Trends in Neurosciences, 2007, 30:399-406.

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George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O’Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences USA, 2007, 104:17198-17203.

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Funk CK, Koob GF. A CRF2 agonist administered into the central nucleus of the amygdala decreases ethanol self-administration in ethanol-dependent rats. Brain Research, 2007, 1155:172-178.

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Funk CK, Zorrilla EP, Lee MJ, Rice KC, Koob GF. Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats. Biological Psychiatry, 2007, 61:78-86.

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Koob GF, Kreek MJ. Stress, dysregulation of drug reward pathways, and the transition to drug dependence. American Journal of Psychiatry, 2007, 164:1149-1159.

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Koob GF. The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. In: Saunders JB, Schuckit MA, Sirovatka P, Regier DA (eds) Diagnostic Issues in Substance Use Disorders: Refining the Research Agenda for DSM-V. American Psychiatric Association, Arlington VA, 2007, pp. 31-43.

*Free full text at Wiley Online Library


Funk CK, O'Dell LE, Crawford EF, Koob GF. Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats. Journal of Neuroscience, 2006, 26:11324-11332.

* Free full text at JNeurosci


Kranzler HR, Koob G, Gastfriend DR, Swift RM, Willenbring ML. Advances in the pharmacotherapy of alcoholism: challenging misconceptions. Alcoholism: Clinical and Experimental Research, 2006, 30:272-281.

* Free full text article at Wiley Online Library


Koob GF. The neurobiology of addiction: a neuroadaptational view relevant for diagnosis. Addiction 2006, 101(Suppl 1):23-30.

* Free full text article at Wiley Online Library


Koob GF. A role for GABA in alcohol dependence. In: Enna SJ (ed) GABA (series title: Advances in Pharmacology, vol 54). Elsevier, New York, 2006, pp. 205-229.

*Free full text at ScienceDirect


O’Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacology Biochemistry and Behavior, 2005, 81:543-550.

*Free full text at ScienceDirect


Koob GF. The neurocircuitry of addiction: implications for treatment. Clinical Neuroscience Research, 2005, 5:89-101.

*Free full text at ScienceDirect


Breese GR, Chu K, Dayas CV, Funk D, Knapp DJ, Koob GF, Le DA, O’Dell LE, Overstreet DH, Roberts AJ, Sinha R, Valdez GR, Weiss F. Stress enhancement of craving during sobriety: a risk for relapse. Alcoholism: Clinical and Experimental Research, 2005, 29:185-195.

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Carrera MRA, Kaufmann GF, Mee JM, Meijler MM, Koob GF, Janda KD. Treating cocaine addiction with viruses. Proceedings of the National Academy of Sciences USA, 2004, 101:10416-10421.

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Zorrilla EP, Koob GF. The therapeutic potential of CRF1 antagonists for anxiety. Expert Opinion on Investigational Drugs, 2004, 13:799-828.

*Abstract at ResearchGate


Koob GF. A role for GABA mechanisms in the motivational effects of alcohol. Biochemical Pharmacology, 2004, 68:1515-1525.

* Free full text at ScienceDirect